The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III):wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain embodiments, said nicotine-derived hapten-carrier conjugates can be used to prepare vaccines for the treatment and/or prevention of nicotine addiction.本發明一部分係關於式(III)之菸鹼衍生之半抗原載體共軛體:其中m、n、W、-(間隔基)-、X*和Y如發明說明中所定義。在某些實施體系中,該等菸鹼衍生之半抗原載體共軛體可用以製備治療及/或預防菸鹼成癮用之疫苗。