PROBLEM TO BE SOLVED: To provide therapeutic methods and compositions comprising inter-leukin 12 (IL-12) useful for treating radiation-induced damage in a subject.SOLUTION: The present invention provides methods and compositions for radiation protection and/or radiation toxicity mitigation for the treatment of acute radiation syndrome and radiation induced toxicity associated with the treatment of cutaneous T-cell lymphoma, by administering a therapeutically effective amount of IL-12.SELECTED DRAWING: Figure 2【課題】対象における放射線誘発損傷を治療するために有用なインターロイキン12(IL-12)を含む治療方法及び組成物の提供。【解決手段】治療上有効量のIL-12を投与することによる急性放射線症候群、及び皮膚T細胞性リンパ腫の治療に関連する放射線誘発毒性の治療のための、放射線防護及び/又は放射線毒性緩和のための方法及び組成物。【選択図】図2