Pottayil G. N. Sasikumar,Muralidhara Ramachandra,Suresh Kumar Vadlamani,K. Rajeev Shrimali,Krishnaprasad Subbarao
申请号：
US14124370
公开号：
US09096642B2
申请日:
2011.12.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides Immunosuppressive compounds capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signalling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides pharmaceutical compositions comprising the Immunosuppressive peptide compounds or modified peptide moieties for preventive and/or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.
