METHODS FOR PREVENTING DISULFIDE BOND REDUCTION IN CELL CULTURE HARVEST

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专利权人:

BAYER HEALTHCARE LLC

发明人:

KWANT, Kathryn

申请号：

SG11202002009P

公开号：

SG11202002009PA

申请日:

2018.09.26

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

This disclosure relates to methods for the prevention of the reduction of disulfide bonds in a polypeptide expressed in a recombinant host cell, comprising, following fermentation, adding phosphate to a harvest solution of the recombinant host cell, wherein the disulfide bond in the polypeptide remains non-reduced.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/