A surgical device (100) for clipping tissue can include a replaceable cartridge (130) comprising a stack of clips (140) contained therein and a firing drive configured to reciprocatingly eject or deploy the clips from the cartridge. The cartridge (130) and/or the surgical device (100) can include a firing chamber (149) wherein the clips (140) can be sequentially pushed into the firing chamber along a supply axis (138). The firing drive can include a firing member which is moved along a firing axis (139) to deploy a clip (140) positioned in the firing chamber (149) wherein the supply axis (138) is transverse to the firing axis.
