The present invention provides a pharmaceutical combination composition and drug combinations for the prophylaxis and/or treatment of dyslipidemic conditions such as high LDL lipemia in mammals including humans. The present invention is related to a pharmaceutical composition for the prophylaxis and/or treatment of dyslipidemia and the like, which comprises (R)-2-[3-[[N-(benzoxazole-2-yl)-N-3-(4-methoxyphenoxy)pro pyl]aminomethyl]phenoxy]butyric acid or a salt thereof or a solvate thereof, and nicotinic acid and nicolinamide collectively named as niacin, an ester derivative thereof, or a salt thereof, or a solvate thereof.本發明提供一種組合醫藥組成物及藥劑併用，其係用以預防及/或治療包含人類之哺乳動物之如高LDL血症之脂質異常狀態。本發明關於一種脂質異常症等之預防及/或治療用醫藥組成物，其含有(R)-2-[3-[[N-(苯并唑-2-基)-N-3-(4-甲氧基苯氧基)丙基]胺基甲基]苯氧基]丁酸或其鹽、或該等之溶劑合物，以及合稱為菸鹼素之菸鹼酸與菸鹼醯胺、或其酯衍生物、或其鹽、或該等之溶劑合物。
