PROBLEM TO BE SOLVED: To provide a prophylactic or curative agent for diabetes, diabetes-related diseases or diabetic complications.SOLUTION: The pharmaceutical comprises as active ingredient a 1-thio-D-glucitol compound of the formula I, or a pharmaceutically acceptable salt thereof or hydrate thereof. This pharmaceutical exhibits SGLT2 activity-inhibitory effect. This pharmaceutical is the prophylactic or curative agent for diabetes, diabetes-related diseases or diabetic complications, in particular.COPYRIGHT: (C)2008,JPO&INPIT【課題】糖尿病、糖尿病関連疾患又は糖尿病性合併症の予防又は治療薬を提供すること。【解決手段】SGLT2の活性阻害作用を示す、下記式で表される1-チオ-D-グルシトール化合物若しくはその製薬学的に許容される塩又はそれらの水和物を有効成分として含有する医薬、特に糖尿病、糖尿病関連疾患又は糖尿病性合併症の予防又は治療薬。【化1】【選択図】なし