A kind of pharmaceutical composition comprising (a) B-Raf inhibitor, (b) EGFR inhibitor, and optionally (c) PI3K inhibitor; Purposes of the combination in treatment proliferative diseases; The method of object with treatment with proliferative diseases comprising apply the combination of therapeutically effective amount.一種藥物組合,其包括(a)B-Raf抑制劑,(b)EGFR抑制劑,和任選(c)PI3K抑制劑;該組合在治療增殖性疾病中的用途;和治療患有增殖性疾病的對象的方法,其包括施用治療有效量的該組合。