INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
Richard D. DIMARCHI,John P. MAYER,Piotr MROZ
申请号：
US16098236
公开号：
US20190218268A1
申请日:
2017.05.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Modified glucagon peptides are disclosed having improved solubility and/or stability while retaining glucagon agonist activity. The glucagon peptides have been modified by the substitution of pyridyl-alanine for a native amino acid at one or more of positions 6, 10 or 13 and/or substitution with an amino acid in the D-conformation at position 20 or 21 compared to native glucagon.
