The present invention is related to a novel antibodies and antibody fragments thereof specifically binding to LAG-3 and a composition comprising the antibodies and antibody fragment thereof. Further, the present invention is related to nucleic acids encoding the antibodies and antibody fragments thereof, and a host cell comprising the nucleic acids, and therapeutic and diagnostic uses.本發明涉及特異性結合LAG-3的新型抗體和抗體片段以及含有所述抗體或抗體片段的組合物。此外,本發明涉及編碼所述抗體或其抗體片段的核酸及包含其的宿主細胞,以及其治療和診斷用途。