methods for treating patient by separating ctcs, capturing circulating tumor cells (ctc) in body fluid and discovering drugs, isolated ctcs, body fluid ctc capture filter and extracorporeal devices for capturing ctcs in body fluid
CORNELIS JOHANNES MARIA VAN RIJN,ILAN REICH,JACOB BAGGERMAN
申请号：
BR112012024350
公开号：
BR112012024350A2
申请日:
2011.03.31
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
methods for treating patient by separating ctcs, to capture circulating tumor cells (ctc) in body fluid and to discover drugs, isolated ctcs, body fluid ctc capture filter and extracorporeal devices for capturing ctcs in body fluid. Embodiments of the present disclosure are directed to the separation / capture of specific cells and / or contaminants, as well as the determination, monitoring and treatment of cancer. In addition, some embodiments are directed to methods, systems and devices for removing cancer cells, stem cells and / or tumor cells in vivo or in vitro from a body fluid to prevent or prevent the proliferation of a cancer. Some embodiments provide a blood-compatible filter comprising, for example, a membrane provided with a series of (preferably more accurate) apertures that produce minimal detrimental effect both quantitatively and qualitatively on cells present in the body fluid during the separation process. For example, in some embodiments, a higher percentage of circulating tumor cells are captured by a filter, while a higher percentage of leukocytes, for example, may pass, in which passing leukocytes retain their vitality.métodos para tratar paciente através da separação de ctcs, para capturar células de tumor circulantes (ctc) em fluido corporal e para descobrir fármacos, ctcs isoladas, filtro de captura de ctcs em fluido corporal e dispositivos extracorpóreos para a captura de ctcs em fluido corporal. as modalidade da presente divulgação são dirigidas para a separação/captura de células e/ou contaminantes específicos, bem como à determinação, monitoração e tratamento do câncer. além disso, algumas modalidades são dirigidas para métodos, sistemas e dispositivos para a remoção de células de câncer, células-troco e/ou de tumor in vivo ou in vitro a partir de um fluido corporal para prevenir ou impedir a proliferação de um câncer. algumas modalidades proporcionam um filtro compatível com sangue, compreendendo, por exemplo, uma membrana dotada de uma
