SEIDEL, RONALD D., III,塞德尔 罗纳德 Ｄ 三世,塞德爾 羅納德 Ｄ 三世,CHAPARRO, RODOLFO J.,查帕罗 鲁道夫 Ｊ,查帕羅 鲁道夫 Ｊ,ROSS, JOHN F.,罗斯 约翰 Ｆ,羅斯 約翰 Ｆ,LOW, CHEE MENG,罗 志鸣,羅 志鳴
申请号：
TW107131342
公开号：
TW201920249A
申请日:
2018.09.06
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present disclosure provides T-cell modulatory multimeric polypeptides T-Cell-MMPs comprising an immunomodulatory polypeptide (“MOD”) that may be selected to exhibit reduced binding affinity to a cognate co-immunomodulatory polypeptide (“Co-MOD”) and location for covalently attaching a molecule that can serve as an epitope, such as an epitope peptide. Once the epitope molecule is attached the resulting T-Cell-MMP-Epitope conjugates are useful for modulating the activity of a T-cell by delivering immunomodulatory peptides, such as IL-2 or IL-2 variants that exhibit reduced binding affinity for IL-2R, to the T-cells in an epitope selective/specific manner, and accordingly, for modulating an immune response in an individual.本發明提供T細胞調節多聚體多肽T細胞-MMP，其包含可經選擇以便對同源共免疫調節多肽(「Co-MOD」)及用於共價附接可充當抗原決定基之分子，諸如抗原決定基肽之位置展現降低之結合親和力的免疫調節多肽(「MOD」)。一旦附接該抗原決定基分子，所得T細胞-MMP-抗原決定基結合物便可用於藉由以抗原決定基選擇性/特異性方式向該T細胞遞送免疫調節肽，諸如對IL-2R展現降低之結合親和力的IL-2或IL-2變異體來調節T細胞之活性，且因此調節個體之免疫反應。
