Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders

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专利权人:

Inc.;Thiogenesis Therapeutics

发明人:

Stanton Jr., Vincent P.,Rioux, Patrice R.

申请号：

AU2017235631

公开号：

AU2017235631A1

申请日:

2017.03.17

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The invention features compositions, methods, and kits containing (i) one or more cysteamine precursor compounds convertible to cysteamine in vivo, and (ii) optionally agents to enhance that conversion, formulated to produce a spectrum of pharmacokinetic profiles of cysteamine that can be tailored to individual patients and diseases. The invention also features varying modes of administration of the therapeutic substances in the treatment of cystinosis and other cysteamine sensitive disorders. In particular, formulations combining active ingredient(s) with pharmaceutical excipients that permit sustained cysteamine plasma concentrations are featured.

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