Якимов Антон Владимирович (RU),Коныгин Григорий Николаевич (RU),Рыбин Дмитрий Станиславович (RU),Елсуков Евгений Петрович (RU),Якимов Кирилл Антонович (RU),Осетров Анатолий Сергеевич (RU),Стрелков Ник
申请号：
RU2013150239/15
公开号：
RU2013150239A
申请日:
2013.11.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The use of a mechanically activated amorphous gluconic acid calcium salt with a homogeneous diffuse halo in its X-ray powder diffraction pattern characterized by the shift of the center of gravity of lines 3000-3600 smv absorption band region of large wave numbers by the amount of not more than 200 cm , the presence of absorption bands with frequencies 3308 ± 20, 2933 ± 10, 1602 ± 10, 1420 ± 10 with an arm 1260 ± 40, 1085 ± 10, 1044 ± 10, 877 ± 10, 682 ± 10, 577 ± 10 smi additional absorption band with the frequency 947 ± 10 smv infrared spectrum, decreasing the endothermic peaks in the temperature range 125-165 ° C and taken HAND peak in the temperature range 30-100 ° C when differential thermal analysis, the presence of a single intensive line with the Lande factor of 2.000 to 2.006 and a width of 8 to 9 E in an electronic paramagnetic resonance spectrum, the appearance of the fine structure unresolved wide line in the regions 60-90 mlnvC and 170-190 NMR spectra shift the resonant lines of their aqueous solutions in 62,8-179,2 mlnna value of not more than 0.1 mlnvC NMR spectra shift the resonant lines of their aqueous solutions in 1,2-4,95 mlnna value of not more than 0.02 mlnvH NMR spe trachea, increasing the peak intensities of 160 m / z mass spectra not less than 2.5 times and 780-1000 m peaks / g extract solution thereof in ethanol not less than three times in a mass-spectroscopic analysis for the treatment nevrozov.2. A method for treating neuroses via pharmaceuticals and other reducing treatments, characterized in that the mechanically activated amorphous gluconic acid calcium salt according to claim 1 administered orally 1-4 times a day in doses of 0.5-2.0 g for 30-40 days intermittently applying 1-2 weeks, in powder form and / or a tablet1. Применение механоактивированной аморфной кальциевой соли глюконовой кислоты с однородным диффузным гало в ее порошковой рентгеновской дифрактограмме, характеризующаяся смещением линий центра тяжести полосы поглощения
