您的位置: 首页 > 农业专利 > 详情页

Diamine derivatives such as leukotriene A4 hydrolase inhibitors
专利权人:
Inc.;Celtaxsys
发明人:
ARNAIZ, Damian,DAVEY, David,GUILFORD, William,CLEVE, Arwed,KIRKLAND, Thomas,CLARET, Emmanuel,KHIM, Seock-Kyu,BROWN, Greg,YE, Bin,LIGHT, David,LIANG, Amy,KOCHANNY, Monica,WEI, Guo,PARKINSON, John
申请号:
ES06848156
公开号:
ES2614090T3
申请日:
2006.12.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound having the following formula (I-1): ** Formula ** in which: R is the group ** Formula ** in which r is 0 to 4, R1a, R1b, R1c, R1d and R1e are each independently hydrogen, -R13-OR10, -R13-C (>; = O) OR10, -R13-C (>; = O) R10, alkyl, halo, haloalkyl, cyano, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroarylalkyl, heterocyclyl, or heterocyclylalkyl; R3 is a direct bond, -O-, -R12-O-, -O-R12-, -O-R12-O-, a linear or branched alkylene chain, a linear or branched alkenylene chain, or a linear or alkynylene chain branched; R4 is a direct bond, -O-R12a-, a linear or branched alkylene chain, a linear or branched alkenylene chain, or a linear or branched alkynylene chain; R8 is aralkyl optionally substituted with one or more substituents selected from the group consisting of halo, nitro, cyano, heteroaryl, hydroxyiminoalkyl, -R13-OR10, -R13-C (>; = O) R10, -R13-C (>; = O ) OR10, -R13-C (>; = O) -R13-N (R10) R11, -R13-C (>; = O) N (R10) -R14-N (R10) R11, -R13-S (>; = O) tN (R10) R11 (where t is 1 or 2), -R13-N (R10) R11, -R13-N (R10) C (>; = O) R10, -R13-N (R10) C (>; = O) -R13-N (R10) R11, -R13-N (R10) -R13-C (>; = O) OR10, -R13-N (R10) C (>; = O) -R14-S ( >; = O) tN (R10) R11 (where t is 1 or 2), -R13-N (R10) C (>; = O) -R13-N (R10) C (>; = O) R10, -R13 -N (R10) C (>; = O) -R13-N (R10) -R14-N (R10) R11, -R13-N (R10) S (>; = O) tN (R10) R11 (where t is 1 or 2), and -R13-O-R14-C (>; = O) OR10; each R9 is independently -O-R10, alkyl, hydroxyalkyl, halo, haloalkyl, aryl or aralkyl; each R10 and R11 is independently hydrogen, alkyl, haloalkyl, hydroxyalkyl, aryl, aralkyl, heteroaryl, heteroarylalkyl, heterocyclyl, or heterocyclylalkyl; or R10 and R11, together with the nitrogen to which they are attached, form an N-heterocyclyl or an N-heteroaryl; R12 is a linear or branched alkylene chain, a linear or branched alkenylene chain, or a linear or branched alkynylene chain; R12a is a linear or branched alkylene chain, a lin
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充