LI, TONG-SHUANG,MCEACHERN, ERNEST J.,VOCADLO, DAVID J.,ZHOU, YUANXI,ZHU, YONGBAO,SELNICK, HAROLD G.
申请号:
CA2840013
公开号:
CA2840013A1
申请日:
2012.06.27
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.