CHRISTOPHER H. HALL,GEORGE WILLIAM FARR,MARC F. PELLETIER,PAUL ROBERT MCGUIRK,WALTER F. BORON
申请号：
BR112014027983
公开号：
BR112014027983A2
申请日:
2013.05.08
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
summary "methods" are the use of selective aquaporin inhibitors, for example aquaporin-4 or aquaporin-2, for example certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, for example. , water imbalance diseases, eg edema (particularly cerebral and spinal cord edema, for example after trauma or ischemic stroke, as well as edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, liver failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, creutzfeldt-jakob disease, and lupus cerebritis, as well as edema due to microgravity and / or radiation exposure, as well as edema due to invasive central nervous system procedures, eg neurosurgery, endovascular clot removal, lumbar puncture (aneurysm repair or deep brain stimulation as well as retinal edema) as well as hyponatremia and excessive fluid retention, and diseases such as epilepsy, retinal ischemia and other eye diseases associated with abnormalities in intraocular pressure and / or hydration. of tissue, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart attack, sepsis and neuromyelitis, as well as migraines, as well as new assays to identify aquaporin inhibitors.resumo "métodos" trata-se do uso de inibidores de aquaporina seletivos, por exemplo, de aquaporina-4 ou aquaporina-2, por exemplo, determinados compostos de fenilbenzamida, para a profilaxia, tratamento e controle de condições mediadas por aquaporina, por exemplo, doenças de desequilíbrio hídrico, por exemplo, edema (particularmente, edema cerebral e da medula espinhal, por exemplo, após trauma ou acidente cerebrovascular isquêmico, assim como o edema associado à glioma, meningite, mal agudo de montanha, ataques epilépticos, infecções, distúrbios metabólicos, hipoxia, intoxicação por água, insuficiência hepática, encefalopa
