Edward John Belouski,Murielle Marie Ellison,Agnes Eva Hamburger,Randy Ira Hecht,Yue-Sheng Li,Mark Leo Michaels,Jeonghoon Sun,Jing Xu
申请号：
US14167662
公开号：
US09493530B2
申请日:
2014.01.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions. In some embodiments, the FGF21 mutant polypeptide comprises a substitution at position 98, 171 and/or 180.
