Katrina Yamazaki;Alan S. Maisel;Guillermo Ceballos;George F. Schreiner;Pam R. Taub;Francisco Villareal;Anne Murphy
发明人:
Francisco Villareal,Pam R. Taub,Alan S. Maisel,George F. Schreiner,Anne Murphy,Katrina Yamazaki,Guillermo Ceballos
申请号：
US13264935
公开号：
US20120095063A1
申请日:
2010.04.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to stimulate mitochondrial function in cells. The methods and compositions described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.
