PERSONALIZED CELLS, TISSUES, AND ORGANS FOR TRANSPLANTATION FROM A HUMANIZED, BESPOKE, DESIGNATED-PATHOGEN FREE, (N0N-HUMAN) DONOR AND METHODS AND PRODUCTS RELATING TO SAME
Paul W. HOLZER,Jon ADKINS,Rodney L. MONROY,Elizabeth J. CHANG
申请号：
US16830213
公开号：
US20200283737A1
申请日:
2020.03.25
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A biological system for generating and preserving a repository of personalized, humanized transplantable cells, tissues, and organs for transplantation, wherein the biological system is biologically active and metabolically active, the biological system having genetically reprogrammed cells, tissues, and organs in a non-human animal for transplantation into a human recipient, wherein the non-human animal does not present one or more surface glycan epitopes and specific sequences from the wild-type swine's SLA is replaced with a synthetic nucleotides based on a human captured reference sequence from a human recipient's HLA.
