A compound of Tau protein is provided. The compound is selectively and strongly bound to β-amyloid protein plaques found in Alzheimers disease. It especially suits to be used as a radiocontrast agent for Alzheimers PET radiography. Or, it can be used to inhibit the β-amyloid protein plaques and stop the proceeding of Alzheimers disease.一種Tau蛋白造影藥物化合物,係關於具選擇性並可強烈地結合至β-類澱粉樣蛋白斑塊之一Tau蛋白造影藥物化合物,其合成方法及其用途,特別係適用與阿茲海默氏症有關之β-類澱粉樣蛋白斑塊之PET造影用之核醫診斷藥物,或用於治療抑制該β-類澱粉樣蛋白斑塊形成並停止阿茲海默氏症之進程之腦神經治療藥物。1‧‧‧2-Acetyl-6-methoxynaphthalene2‧‧‧2-Acetyl-6-hydroxynaphthalene3‧‧‧2-Acetyl-6-[(2-hydroxyethyl)methylamino]naphthalene4‧‧‧2-(1,1-Dicyanopropen-2-yl)-6-[(2-hydroxyethyl)methylamino]naphtha-lene5‧‧‧2-(1,1-Dicyanopropen-2-yl)-6-{[2-(2-hydroxy-ethoxy)-ethyl]methy1amino}naphthalene6‧‧‧Tau蛋白造影藥物化合物
