USE OF MUTANT HERPES SIMPLEX VIRUS-2 FOR CANCER THERAPY

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专利权人:

BAYLOR COLLEGE OF MEDICINE

发明人:

ZHANG, XIAOLIU,FU, XINPING

申请号：

CA2613310

公开号：

CA2613310C

申请日:

2006.06.23

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present invention is directed to the composition and use of a modifiedHerpes Simplex Virus Type 2 (HSV-2)as a medicament in the treatment of cancer. The modified HSV-2 has fusogenicactivity, and comprises a modified/mutated ICP10polynucleotide encoding a polypeptide having ribonucleotide reductase activityand lacking protein kinase activity.

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