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CONSTRUCTION DE FUSION D'UNE ENTITÉ D'EFFECTEUR FAB ANTI-ALBUMINE SÉRIQUE, ET PROCÉDÉ DE PRÉPARATION DE LADITE CONSTRUCTION
专利权人:
Ltd;Aprilbio Co.
发明人:
申请号:
EP14839630.2
公开号:
EP3039038A4
申请日:
2014.08.29
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to antigen-binding fragment(Fab) and a Fab-effector fusion protein or (poly)peptide comprising thereof. The Fab of the present invention specifically binds to serum albumin and thereby has extendedin vivohalf-life. The Fab of the present invention is characterized by not having cysteine residues that are responsible for the interchain disulfide bond in C<;sub>;H1<;/sub>;domain and C<;sub>;kL<;/sub>;domain as well. The Fab-effector fusion protein or (poly)peptide of the present invention can be produced in periplasm ofE. coliwith high yield, and has increasedin vivohalf-life. Further, the present invention providesE. colistrain which produces various kinds of Fab-effector fusion proteins or (poly)peptides, and a pharmaceutical composition comprising the fab-effector fusion proteins or (poly)peptides.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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