JASPART SVERINE FRANCINE ISABELLE,PLATTEEUW JOHANNES JAN,VAN DEN HEUVEL DENNY JOHAN MARIJN
申请号：
IN201817001352
公开号：
IN201817001352A
申请日:
2018.01.12
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The invention provides an orodispersible solid pharmaceutical dosage unit having a weight between 30 and 1 000 mg said dosage unit consisting of: 0.1 25 wt.% of estetrol particles containing at least 80 wt.% of an estetrol component selected from estetrol estetrol esters and combinations thereof and 75 99.9 wt.% of one or more pharmaceutically acceptable ingredients the solid dosage unit comprising at least 100 g of the estetrol component and wherein the solid dosage unit can be obtained by a process comprising wet granulation of estetrol particles having a volume weighted average particle size of 2 m to 50 m. The solid dosage unit is easy to manufacture and perfectly suited for sublingual buccal or sublabial administration.
