PROBLEM TO BE SOLVED: To provide formulations having excellent dispersion stability and excellent ingestibility (deglutition), simultaneously with excellent retentivity to the mucosa of an organ with a short transit time, such as oral cavity or esophagus, in formulations containing sucralfate and to provide a production method thereof.SOLUTION: A formulation is obtained by compounding two or more kinds of (E) water-soluble anionic polymer compounds, which are not gelated by a divalent metal ion, into a gel composition obtained by compounding (D) a neutralized thickener to a liquid composition and adjusting a pH to 5-8, the liquid composition containing (A) sucralfate, (B) organic acid, and (C) water, wherein the formulation mass ratio represented by (A)/(C) is 0.8-6, and the content of the component (B) is 7.5-40 mass%.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】スクラルファートを含有する製剤において、口腔や食道のような通過時間の短い器官の粘膜に対する良好な滞留性を有すると共に、分散安定性及び服用性(嚥下性)にも優れた製剤及びその製造方法を提供する。【解決手段】(A)スクラルファート、(B)有機酸、及び(C)水を含有し、(A)/(C)で表される配合質量比が0.8~6であり、(B)成分の含有量が7.5~40質量%である液状組成物に対して、(D)中和増粘剤を配合してpHを5~8に調整して得たゲル組成物に、(E)2価の金属イオンによってゲル化しない水溶性アニオン性高分子化合物を2種以上配合して得られる製剤。【選択図】なし
