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Molecular assembly using branched amphiphilic block polymer, and drug transportation system
专利权人:
SHIMADZU CORPORATION;KYOTO UNIVERSITY
发明人:
Isao Hara,Eiichi Ozeki,Shunsaku Kimura,Akira Makino
申请号:
US14425429
公开号:
US09623122B2
申请日:
2013.09.03
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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