Raymond Tsang,Jody Berry,Xin Yuan,Cindi Corbett,Mike Gubbins,Amin Kabani,Lisa Schmidt
申请号：
US12301034
公开号：
US08753635B2
申请日:
2007.05.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The characterization and isolation of F20G75, F20G76 and F20G77, anti-PA monoclonal antibodies which also have neutralizing activities is described. The monoclonal antibodies may be used as a pharmaceutical composition for treating individuals suspected of or at risk of or having a Bacillus anthracis infection. The monoclonal antibodies bind to a specific region comprising amino acids 311-316 of PA, ASFFDI or a larger fragment comprising amino acids 301-330 of PA, SEVHGNAEVHASFFDIGSSVSAGFSNSNSS. Vaccines comprising these peptides may be used to immunize individuals against Bacillus anthracis infection.
