PROBLEM TO BE SOLVED: To provide a method for producing a granule composition having suitable sizes, uniform granule size distribution and a high medicine content uniformity for each of granule sizes and giving tablets obtained by compression-forming of the same, having characteristics equipped with high hardness and good disintegrating time simultaneously.SOLUTION: This method for producing a granule composition is characterized by using functional starch powder having &ge400% water-retaining amount, 100-3,000 g gel indentation load and 40-95% water-soluble components as a binder, and wet-granulating the powdery granules containing &ge1 kind of active ingredient having 0.0001 to 10 g/L solubility in water.COPYRIGHT: (C)2007,JPO&INPIT【課題】 適度な大きさで均一な粒度の分布を持ち、粒度毎の薬物含量均一性が高く、圧縮成形して得られる錠剤が高い硬度と良好な崩壊時間を兼ねそなえた圧縮成形特性を有する造粒組成物の製造方法を提供すること。【解決手段】 保水量が400%以上、ゲル押込み荷重が100~3000g、水溶性成分が40~95%である機能性澱粉粉末を結合剤として用い、水への溶解度が0.0001~10g/Lの1種以上の活性成分を含む粉粒体を湿式造粒することを特徴とする、造粒組成物の製造方法。【選択図】 なし
