新的羥基－6－雜芳基菲啶及其作為PDE4抑制劑的用途

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专利权人:

TAKEDA GMBH

发明人:

BEATE SCHMIDT,DIETER FLOCKERZI,ARMIN HATZELMANN,CHRISTOF ZITT,JOHANNES BARSIG,DEGENHARD MARX,HANS-PETER KLEY,ULRICH KAUTZ

申请号：

HK15109596.2

公开号：

HK1208865A

申请日:

2015.09.30

申请国别(地区):

HK

年份:

2016

代理人:

摘要：

Compounds of formula I in which R1 is methoxy, R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy, R3 is hydrogen, R31 is hydrogen, R4 is -O-R41, in which R41 is hydrogen, R5 is hydrogen, Har is substituted by R6 and R7, and is pyridinyl, in which R6 is oxo, and R7 is methyl, or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof are novel effective PDE4 inhibitors.

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