PROBLEM TO BE SOLVED: To provide a new ALS (Amyotrophic Lateral Sclerosis) prevention therapeutic agent.SOLUTION: An amyotrophic lateral sclerosis prevention therapeutic agent includes crocetin or a sugar ester thereof as an active ingredient. Moreover, in the amyotrophic lateral sclerosis prevention therapeutic agent, crocetin or a sugar ester thereof is crocetin-β-D-gentiobiosyl-β-D-glucosyl ester.COPYRIGHT: (C)2013,JPO&INPIT【課題】新たなALS予防治療剤の提供。【解決手段】クロセチン又はその糖エステルを有効成分とする筋萎縮性側索硬化症予防治療剤。【選択図】なし