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COMPOSITIONS D'ARNI DE CETOHEXOKINASE (KHK) ET PROCEDES POUR LES UTILISER
- 专利权人:
- ALNYLAM PHARMACEUTICALS; INC.
- 发明人:
- FITZGERALD, KEVIN,BETTENCOURT, BRIAN,HINKLE, GREGORY,WILLOUGHBY, JENNIFER
- 申请号：
- CA2938857
- 公开号：
- CA2938857A1
- 申请日:
- 2015.02.11
- 申请国别(地区):
- CA
- 年份:
- 2015
- 代理人:
- 摘要：
- The present invention relates to RNAi agents, e.g., double- stranded RNAi agents, targeting the ketohexokinase (KHK) gene, and methods of using such RNAi agents to inhibit expression of KHK and methods of treating subjects having a KHK-associated disorder, e.g., liver disease (e.g., fatty liver, steatohepatitis), dyslipidemia (e.g., hyperlipidemia, high LDL cholesterol, low HDL cholesterol, hypertriglyceridemia, postprandial hypertriglyceridemia), disorders of glycemic control (e.g., insulin resistance, diabetes), cardiovascular disease (e.g., hypertension, endothelial cell dysfunction), kidney disease (e.g., acute kidney disorder, tubular dysfunction, proinflammatory changes to the proximal tubules), metabolic syndrome, adipocyte dysfunction, visceral adipose deposition, obesity, hyperuricemia, gout, eating disorders, and excessive sugar craving.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
