TYKOCINSKI, MARK L.,SHANI, NOAM,GOZLAN, YOSI,DRANITZKI ELHALEL, MICHAL,BREMER, EDWIN,KAMINSKY, IDO
申请号：
CA3047707
公开号：
CA3047707A1
申请日:
2018.01.04
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
PD1-41BBL fusion proteins are provided. Accordingly, there is provided a PD1-41BBL fusion protein comprising a single amino acid linker between the PD1 and the 41BBL. Also there is provided a PD1-41BBL fusion protein, wherein the PD1 amino acid is 123-166 amino acids in length and/or wherein the PD1 amino acid sequence comprises SEQ ID NO: 2 and/or wherein the fusion protein is in a form of at least a homo-trimer. Also provided are polynucleotides and nucleic acid constructs encoding the PD1-41BBL fusion protein, host-cells expressing the PD1-41BBL fusion protein and methods of use thereof.
