Herein are reported humanized anti-IL-1beta antibodies that are humanized variants of the murine anti-IL-1beta antibody H34. A specific humanized antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 25, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 27, and (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 28.Linvention concerne des anticorps anti-IL-1bêta humanisés qui sont des variantes humanisées de lanticorps anti-IL-1bêta H34. Un anticorps humanisé spécifique comprend (a) un HVR-H1 renfermant la séquence dacides aminés de SEQ ID NO: 25, (b) un HVR-2 renfermant la séquence dacides aminés de SEQ ID NO: 27, et (c) un HVR-H3 renfermant la séquence dacides aminés de SEQ ID NO: 28.
