PURPOSE: A method and composition for promoting skin regeneration using icariside II is provided to promote proliferation of transient amplifying cells of epidermis base and promote skin regeneration. CONSTITUTION: An icariside II of chemical formula 1 promotes proliferation of skin cells in skin cells. The skin cell is transient amplifying cells(TA cells). A composition for promoting skin regeneration contains the icariside II as an active ingredient. The content of the active ingredient is 0.001-10 weight% based on total weight. The composition regenerates epidermis by promoting proliferation of the TA cells. The composition increases the number of TA cells which express CD71 protein (Cluster of Differentiation 71 Protein) and &alpha；6 integrin. The composition increases the expression of CD200(Cluster of Differentiation 200).본 발명은 피부세포의 증식을 촉진하는 방법 및 이카리시드 II(Icariside II)를 유효 성분으로 함유하는 피부 재생 촉진용 조성물을 개시한다.본 발명에 따른 피부세포의 증식을 촉진하는 방법 및 조성물은 표피의 재생에 관여하는 피부 표피 기저층의 전이-증폭 세포의 증식을 촉진할 수 있는 바, 이를 통해 피부의 재생을 촉진할 수 있다.
