The present invention relates to the methods of filler for removing wrinkles comprising: elongate tubular body can be set to across hypodermic layer And the histocyte for around guide through hole enters in main body, to form fibr tissue, wherein forming through-hole, leads intracorporal hollow portion in the longitudinal direction from main body described in outer surface with being formed in. Filler for removing wrinkles of the invention and deform or move the pressure on skin or by the external force of appearance in insertion subcutaneous tissue, can be applied to have various physical feelings wrinkly, including deep wrinkle. In addition, the filler of the invention of wrinkle improvement effect can be (partly) long-term continue.
