BEHENNA, DOUGLAS CARL,CHENG, HENGMIAO,CHO-SCHULTZ, SUJIN,JOHNSON JR., THEODORE OTTO,KATH, JOHN CHARLES,NAGATA, ASAKO,NAIR, SAJIV KRISHNAN,PLANKEN, SIMON PAUL
申请号：
PL14806447
公开号：
PL3071570T3
申请日:
2014.11.10
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
