LU, Hong Fang,LEONG, Meng Fatt,LIM, Tze Chiun,WAN, Andrew Chwee Aun
申请号：
EP20160796847
公开号：
EP3294870(A4)
申请日:
2016.05.16
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
The present invention relates to a method for producing a contractile cellular construct, comprising the steps of: a) seeding pre-selected cells onto a mold, wherein the pre-selected cells comprise signal emitting agents; and b) culturing the pre-selected cells to produce the cellular construct. The said method is exemplified by mixing cardiomyocytes with fluorescent microbeads, seeding the suspension on a polydimethylsiloxane (PDMS) mold and culturing to form a contractile device comprising of cardiac muscles. The present invention also relates to a method for measuring the contractility of the cellular construct by measuring the displacement of the signal emitting agents, and a method for screening a method for screening one or more agents for modulating the contractility of a contractile cellular construct.
