CONJUGUES ANTICORPS ANTI-VEGFR-2-UREASE

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专利权人:

HELIX BIOPHARMA CORPORATION

发明人:

CHAO, HEMAN,WONG, WAH YAU,TIAN, BAOMIN,UGER, MARNI DIANE

申请号：

CA3049272

公开号：

CA3049272A1

申请日:

2018.01.04

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Antibody-urease conjugates having therapeutic utility are provided. More specifically, described herein are anti-VEGFR-2 antibody-urease conjugates for the treatment of solid tumors. A conjugate comprising an anti-VEGFR-2 antibody moiety conjugated to a urease moiety is described. Compositions and methods are also described for the treatment of VEGFR-2 dependent tumors, incorporating the antibody-urease conjugates described herein.

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