The present disclosure pertains to a system and method for controlling insufflation pressure during inexsufflation of a subject. The system inexsufflates the subject such that tidal flow and/or tidal volume are monitored during insufflation, and insufflation pressure is adjusted to maintain the flow rate of the pressurized flow of breathable gas until a target tidal volume is reached for the insufflation. When the target tidal volume has substantially been reached, the system is causes gas to be evacuated from the airway of the subject. This may provide for more precise, customized therapy for the subject than is provided by conventional inexsufflation systems in which inspiratory flow may not be monitored and/or controlled. In one embodiment, the system comprises one or more of a pressure generator, a subject interface, one or more sensors, a processor, a user interface, electronic storage, and/or other components.
