The present invention provides a phosphorus-containing pyrido [2, 3-d] pyridine-7-ketone compound represented by formula (I) or a pharmaceutically acceptable slat thereof. This invention also discloses a preparation method of the compound, a pharmaceutical composition comprising the phosphorus-containing pyrido [2, 3-d] pyridine-7-ketone compound and applications thereof. The compound is a protein kinase (for example PI3K) inhibitor capable of treating diseases caused by abnormal activity of the protein kinase, such as a tumor.本發明提供了一類如式(I)所示的含磷吡啶並[2,3-d]嘧啶-7-酮類化合物或其在藥學上可接受的鹽,同時還公開了該化合物的製備方法、包含所述含磷吡啶並[2,3-d]嘧啶-7-酮類化合物的藥物組合物及其用途。這類化合物是蛋白激酶(例如PI3K)抑制劑,可用於治療因蛋白激酶活性異常所引起的疾病,例如腫瘤等。無。
