Borisov Valerij Aleksandrovich (RU),Борисов Валерий Александрович (RU),BORISOV VALERIJ ALEKSANDROVICH
申请号:
RU2011131712/15
公开号:
RU0002459629C1
申请日:
2011.07.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely hepatology and may be applicable in treating chronic viral hepatitis C. That is ensured by introducing short-lived interferon-alpha (IFN) and the nucleoside analogue Ribamidil in the patient with an initial average week dosage specified in the range of 10.5 to 21.0 mil. IU depending on the level of native patient's interferon-alpha. Interferon-alpha is introduced with at least twice gradually increase of the average week dose to 21.0 to 84 mil. IU. Over the whole period of introducing IFN, the patient is prescribed with additional antiviral preparations - an interferon inducer, as well as an amantadin preparation or a glycyrrhizic acid preparation. It is combined with a support therapy involving the introduction of T-cell immunity stimulators and preparations for correction of side effects. The presence of blood viral ribonucleic acid is occasionally controlled and the introduction of Ribamidil is started in a daily dose of 800-1200 mg from the third month from the beginning of treatment if observing the presence of ribonucleic acid or from the tenth month if observing the absence. The treatment is continued until at least a 12-month aviremia period is achieved.EFFECT: using the presented method allows reducing aggression of antiviral therapy combined with increase of a stable positive therapeutic effect.4 ex, 2 tbl, 2 dwgИзобретение относится к медицине, а именно к гепатологии, и может быть использовано при лечении хронического вирусного гепатита С. Для этого больному вводят короткоживущий интерферон-альфа (ИФН) и аналог нуклеозидов рибамидила, определяя стартовую среднюю недельную дозу в интервале от 10,5 до 21,0 млн ME в зависимости от уровня собственного интерферона-альфа больного. Введение интерферона-альфа осуществляют при, по меньшей мере, двукратном ступенчатом повышении средней недельной дозы интерферонов до значений от 21,0 до 84 млн ME. На протяжении всего времени введения ИФН больному ввод