This disclosure describes various systems for collecting thermal measurements of regions of a user's face. Each of the systems includes a frame configured to be worn on the user's head, and one or more lightweight thermal cameras that are coupled to the frame and configured to take thermal measurements of a region of interest on the user's face. Due to their coupling to the frame, the thermal cameras remain pointed at their respective regions of interest event when the user's head performs angular movements. The thermal measurements collected by some embodiments of the systems described herein may be utilized for a variety of applications that involve detecting different types of physiological responses or medical disorders.