COMPOSITIONS PHARMACEUTIQUES A DOUBLE ACTION FONDEES SUR DES SUPERSTRUCTURES DE RECEPTEUR ANTAGONISTE/BLOQUEUR D'ANGIOTENSINE ET D'INHIBITEUR D'ENDOPEPTIDASE NEUTRE
AL-FAYOUMI, SULIMAN,HU, JIAHUI,KUMARAPERUMAL, NATRAJAN,ROYCE, ALAN EDWARD,RUEGGER, COLLEEN,ZANNOU, ERIKA AINA
申请号：
CA2703598
公开号：
CA2703598C
申请日:
2008.11.04
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Solid oral dosage forms, especially tablets, of a pharmaceutical compositioncomprising a supramolecularcomplex can be formed from a direct compression process or a compactionprocess such as roller compaction. Such solid oral dosageforms feature an immediate release profile that allows for fast release of thetherapeutic agent. A particularly usefulsupramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-l-butylcarbamoyl)propionate-(S)-3'-methyl-2'-(pentanoyl {2"-(tetrazol-5-ylate)biphenyl-4'-ylmethyl } amino)butyrate]hemipentahydrate.
