BICKNELL, ROY,SUCHTING, STEVEN,STEWART, LORNA MARY DYET
申请号：
CA2506724
公开号：
CA2506724C
申请日:
2003.11.20
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
A method of inhibiting angiogenesis in an individual in need thereofcomprising administering an antibody that selectively binds to theextracellular region of human magic roundabout (MR) to the individual. Anantibody that has the amino acid sequences i) to iii), the amino acidsequences iv) to vi), or the amino acid sequences i) to vi): i) S A S S S V SY M Y ii) L T S N L A S iii) Q Q W S S N P L T iv) D Y N L N v) V I N P N Y GT T S Y N Q K F K G vi) G R D Y F G Y. A method of inhibiting angiogenesis inan individual in need thereof comprising administering the extracellulardomain (residues 1-467) of MR, or a fragment thereof that inhibitsangiogenesis, to the individual. A method of inhibiting endothelial cellmigration and/or proliferation comprising administering the extracellulardomain of MR, or a fragment thereof that inhibits endothelial cell migrationand/or proliferation.
