PROBLEM TO BE SOLVED: To provide a curative medicine or a preventive medicine of articular rheumatism having p38MAPK inhibitory activity and TNFα-production inhibitory activity accompanied by the p38MAPK inhibitory activity, and achieved in both a favorable in-vivo kinetics profile as a medicine and the reduction of hepatotoxicity.SOLUTION: There is provided the curative medicine or the preventive medicine of the articular rheumatism containing a 2,3-dihydro-1H-inden-2-yl urea derivative expressed by a formula (1), or a salt permitted in terms of pharmacology as an effective component.COPYRIGHT: (C)2013,JPO&INPIT【課題】p38MAPK阻害活性及びこれに伴うTNFαの産生抑制活性を有し、医薬品として良好な体内動態プロファイルと肝毒性の低減の双方を実現した関節リウマチの治療剤又は予防剤を提供すること。【解決手段】本発明は、一般式(I)で示される、2,3-ジヒドロ-1H-インデン-2-イルウレア誘導体又はその薬理学的に許容される塩を有効成分として含有する、関節リウマチの治療剤又は予防剤を提供する。【選択図】なし
