YU, YIYUN,PENNIG, THOMAS D.,POHLKI, FRAUKE,GUILLIER, FABRICE,POTIN, DOMINIQUE,KLING, ANDREAS,DOHERTY, GEORGE,TAO, ZHI,FU - DAI, YUJIA,WANG, XILU,SONG, XIAOHONG,BRAJE, WILFRIED,RISI, ROBERTO,BRADY, PAT
申请号：
ARP180102345
公开号：
AR112415A1
申请日:
2018.08.15
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
Preparations for the treatment of diseases and diseases, including cancer. A pharmaceutical synthesis including a formula compound (1) is also provided. 1. Characteristic 1: a compound of formula (1) or a salt which can be extracted from it and accepted by the drug,A3 is n, a8308es cr8308； 74919；A8310s is C, or A2,A3 is n, a8308es or s, a8310s is C； or A2 is CR2,A3 is C, a8308es or s, a8310es C； or a ′ n, A3 is C, a8308es or s, a8310es C； or a ′ n, A3 is C, a8308es cr8308； a749191；A8310es n； RA is hydrogen, ch832323；Halogen, CN, ch8322； (F, chf832222)；O CF83223；X is O, o n (r739)；R739o2 is hydrogen, c83321833183323 is tar；O bicycle not replaced； and (CH 8322244)；-CH=CH-（CH832224）-8345；--（CH832222）-8346；-CH=CH-，o-（CH8322）Q-CH=CH-（CH832222）691-；Among them, 0, 1, 2, or 3 c83222 groups were composed of O, n (r696)； 74919；c（R696）；7491（R696）；7495；it is life.NC（O）R6966；74919；o S（o）832222；M is 2, 3, 4 or 5； n is 1, 2, or 3； P is 1, 2, or 3； q is 1 or 2； R is 1 or 2； the sum of Q and R is 2 or 3； r6966； 74911；In each case, it is an independent hydrogen, alquenilo c832283331-832626；1. C 83228331 asphalt；G1,1. Lease land No. c833218331 and 832626；o Halogalo C83218C8331832626；There, alquenilo c83322831832626,1. C 83228331 asphalt；1. Lease land No. c833218331 and 832626；And the halide c833218331832626, which can be replaced by one or two alternatives independent of oxo-n (r6966)； 74966 (r6966)； 74976 (r977)；G1,-Or696；-75844；-SR696；-75011；-S（O）8322；（R696）；74969（R696）；74977；Y-S（O）832222-G1；Y r696； 74959 is alquenilo c83322832626；1. C 83228331 asphalt；G1,1. Lease land No. c833218331 and 832626；o Halogalo C83218C8331832626；There, alquenilo c83322831832626,1. C 83228331 asphalt；1. Lease land No. c833218331 and 832626；And the halide c833218331832626, which can be replaced by one or two alternatives independent of oxo-n (r6966)； 74966 (r6966)； 74976 (r977)；G1,-Or696；-75844；-SR696；-75011；-S（O）8322；（R696）；74969（R696）；74977；Y-S（O）832222-G1；O r696； 7491 and r696； 74955；A. a c833183277 sing
