Disclosed are compositions related to a substantially non-cytotoxic chlorine dioxide solution. The solution may be a thickened fluid composition. Also disclosed are methods of making and using a substantially non-cytotoxic thickened fluid compositions or solutions comprising chlorine dioxide solution. An oxidizing composition of reduced irritation is also disclosed.本發明揭示一種與實質上不具細胞毒性之二氧化氯溶液相關之組合物。該溶液可為稠化流體組合物。亦揭示一種製造及使用包含二氧化氯溶液之實質上不具細胞毒性之稠化流體組合物或溶液的方法。亦揭示降低刺激性之氧化組合物。