CORTE, JAMES R.,柯德 詹姆士R,柯德 詹姆士R,DELUCCA, INDAWATI,德鲁卡 印达瓦提,德魯卡 印達瓦提,FANG, TIANAN,方天安,方天安,YANG, WU,杨 武,楊 武,WANG, YUFENG,王裕丰,王裕豐,DILGER, ANDREW K.,戴尔杰 安德鲁K,戴爾傑 安德魯K,PABBISETTY, KUMAR BALASHANMUGA,帕比斯提 库
申请号：
TW104103315
公开号：
TW201615640A
申请日:
2015.01.30
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.本發明提供式(Ia)化合物:或其立體異構體、互變異構體或醫藥學上可接受之鹽,其中所有變數如本文所定義。此等化合物為選擇性因子XIa抑制劑或FXIa及血漿激肽釋放素之雙重抑制劑。本發明亦關於包含此等化合物之醫藥組合物及使用其治療血栓栓塞及/或發炎性病症之方法。
