Multispecific antibodies, antibody analogs, compositions and methods

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专利权人:

ジェネンテック, インコーポレイテッド;インコーポレイテッド;ジェネンテック，

发明人:

シーア， ジャスティン,ヴァンドレン， リチャード エル．,シーア, ジャスティン,ヴァンドレン, リチャード エル.

申请号：

JP2012542225

公开号：

JP6184695B2

申请日:

2010.12.03

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

Multispecific antibodies that specifically bind at least two different epitopes are provided. Structural variants of native antibodies (antibody analogs) are also provided. Also provided are multispecific antibodies and antibody analogs having a range of biological activities. Agonist and antagonist multispecific antibodies and agonist and antagonist antibody analogs are provided. Multispecific antibodies and antibody analogs conjugated with therapeutic and/or diagnostic agents are also provided, as are multispecific antibodies and antibody analogs conjugated with agents to increase in vivo half-life compared to multispecific antibodies and antibody analogs lacking such agents. In addition, methods of making multispecific antibodies and antibody analogs and compositions comprising multispecific antibodies and antibody analogs are provided. Therapeutic, research, and diagnostic uses of multispecific antibodies and antibody analogs are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/