A compound represented by Formula (I): [Chemical Formula 1] wherein Z1 is C(R4) or the like； R4 is a hydrogen atom or the like； Z2 is C(R5a)(R5a') or the like； a dashed line represents the presence or absence of a bond； when the dashed line represents the presence of a bond, then R5a' is absence； R5a and R5a' are each independently a hydrogen atom or the like； a ring Q is a substituted or unsubstituted 5-membered non-aromatic heterocycle or the like； Y1 is O or the like； R2a is a group represented by Formula: -(C(R2a')(R2b'))n-R1； R2b is a hydrogen atom or the like； R2a' and R2b' are each independently a hydrogen atom or the like； R1 is substituted or unsubstituted aromatic carbocyclyl or the like； X is N(R7a) or the like； R7a is a hydrogen atom or the like； R3 is substituted or unsubstituted aromatic carbocyclyl or the like； n is an integer from 0 to 4； m is an integer from 0 to 4； or a pharmaceutically acceptable salt thereof.本發明係提供具有P2X7受體抑制作用之新穎化合物及具有P2X7受體抑制作用之醫藥組成物。一種式(I)： (式中，Z1為C(R4)等；R4為氫原子等；Z2為C(R5a)(R5a’)等；虛線表示鍵結存在或不存在；虛線表示鍵結存在時，R5a’不存在；R5a及R5a’各自獨立地為氫原子等；環Q為經取代或未經取代之五員非芳香族雜環等；Y1為O等；R2a為式：-(C(R2a’)(R2b’))n-R1所示之基；R2b為氫原子等；R2a’及R2b’各自獨立地為氫原子等；R1為經取代或未經取代之芳香族碳環式基等；X為N(R7a)等；R7a為氫原子等；R3為經取代或未經取代之芳香族碳環式基等；n為0至4的整數；m為0至4的整數)所示之化合物或其製藥上容許之鹽。
